What is the difference between adding and buying a full imaging system?

Adding an imaging module to an existing host instrument costs less, takes a shorter cycle and retains the original workflow; buying a full system is optimized for dedicated imaging but requires higher investment.

Can my mass spectrometer be fitted with a Neo-Source imaging source?

Neo-Source LDPI/DPI are compatible model-by-model with mainstream mass spectrometers such as Agilent, SCIEX and Thermo; please refer to the official compatibility list for specifics.

Can I still do my original analysis after adding?

Yes. Added imaging sources are mostly switchable modules, and the host instrument can still perform routine LC-MS/GC-MS analysis when not in use.

What needs to be evaluated before adding?

Evaluate host-instrument compatible models, interface support, software reconstruction capability, manufacturer installation and training, and it is recommended to first validate resolution and repeatability with a small sample.

Product · Neo-Source

Adding a mass spectrometry imaging ion source (upgrading existing mass spectrometer to imaging)

Adding refers to adding an independent imaging ion source module to an existing mass spectrometry platform, upgrading the original instrument from routine analysis to one with spatial imaging capability. Compared with purchasing a full imaging system, adding reuses the existing host instrument investment at a lower cost and shorter cycle, making it a pragmatic choice for gradual expansion.

Table of Contents
1. How adding is implemented 2. Target users 3. Evaluation before adding

Adding a mass spectrometry imaging ion source (upgrading existing mass spectrometer to imaging) — schematic diagram

1. How adding is implemented

Adding usually appears as an independent ionization-scanning module connected to the host analyzer through a standard interface; the sample is scanned and imaged on an independent positioning platform, while the host instrument retains its original routine analysis mode. Before and after adding, the team does not need to relearn a brand-new system, only switching between imaging and normal modes.

Compared with 'full-system replacement', adding retains the original instrument's quantification/screening workflow and warranty relationship, reducing management complexity and avoiding resource waste from equipment idleness.

2. Target users

The add-on solution suits teams that already own mainstream mass spectrometers such as Agilent/SCIEX/Thermo and wish to try imaging, as well as research projects with limited budgets but needing specific spatial-distribution data. It lets imaging capability be 'enabled on demand' rather than a one-time heavy-asset investment.

The model-by-model design of Neo-Source LDPI/DPI targets such add-on needs, compatible with mainstream host instruments containing TOF/Orbitrap/QQQ, enabling users to gain ambient matrix-free or high-sensitivity imaging in a modular way.

3. Evaluation before adding

Before adding, verify: whether the host instrument is on the manufacturer's compatibility list, whether the interface and vacuum/ambient transition are supported, whether the imaging software can complete coordinate-spectrum reconstruction and export standard formats, and whether the manufacturer provides installation and training. It is recommended to first validate key metrics with a small sample.

Overall, adding is a low-cost entry point that turns 'wanting to do imaging' into 'being able to do imaging'; whether to expand further can be driven by validation results.

Neo-Source MSI LDPI Laser Desorption Photoionization Imaging Source

Matrix-free:No organic matrix spraying required; m/z>=70 low background, well suited to small-molecule drugs and metabolites

Ambient operation:Works in open ambient environment; simplified sample preparation; supports near in-situ / in-vivo analysis

Resolution:2-3 um spatial resolution, among the leading in the industry, reaching single-cell / subcellular scale

Modular compatibility:External add-on design; model-by-model compatibility with Agilent / SCIEX / Thermo mainstream MS hosts

View LDPI specifications and compatible models →

Frequently Asked Questions (FAQ)

What is the difference between adding and buying a full imaging system?: Adding an imaging module to an existing host instrument costs less, takes a shorter cycle and retains the original workflow; buying a full system is optimized for dedicated imaging but requires higher investment.
Can my mass spectrometer be fitted with a Neo-Source imaging source?: Neo-Source LDPI/DPI are compatible model-by-model with mainstream mass spectrometers such as Agilent, SCIEX and Thermo; please refer to the official compatibility list for specifics.
Can I still do my original analysis after adding?: Yes. Added imaging sources are mostly switchable modules, and the host instrument can still perform routine LC-MS/GC-MS analysis when not in use.
What needs to be evaluated before adding?: Evaluate host-instrument compatible models, interface support, software reconstruction capability, manufacturer installation and training, and it is recommended to first validate resolution and repeatability with a small sample.

Get Specifications & Quotation

To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).

External MSI Ion Source (modular expansion solution)MSI ion source retrofit kit (modular external add-on)Neo-Source MSI LDPI Laser Desorption Photoionization imaging ion source DPI Dual-Photoionization Imaging Source MSI Ion Source

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