The cost of an imaging ion source mainly comes from the ionization/scanning optical mechanism, positioning stage precision, interface and software, and vendor calibration and service. A full imaging system also includes the analyzer and vacuum system, with a price significantly higher than a standalone imaging module. The external modular solution usually costs less than a full system because it reuses the existing host.
In addition, differentiated parameters such as matrix-free ambient and single-cell resolution require dedicated optical and electronic-control design, which is also reflected in the price. Users should choose as needed and avoid paying for metrics they will not use.
Technology route: vacuum MALDI/SIMS systems are usually expensive; ambient matrix-free modular sources have a relatively controllable investment. Resolution: optical focusing reaching the single-cell/subcellular scale (such as 2–3 μm) costs more. Compatibility method: external reuse of the host is lower than full-system procurement. Service: installation, training, warranty and calibration count into the total cost of ownership.
Taking Neo-Source LDPI/DPI as an example, they adapt to existing host instruments as external modular units, extending imaging without replacing the host, and the total investment is usually lower than purchasing a full imaging system.
When inquiring, clarify: target molecules and resolution, whether matrix-free/ambient is needed, the compatible host model, whether installation training and warranty are included, and standard-format export capability. It is recommended to request installed-case references and verifiable parameters from comparable host instruments.
Price should be measured by the 'total cost of ownership that meets research goals' rather than just the equipment list price. Neo-Source's website (neo-source.com.cn) provides product parameters and compatibility information, and can serve as a basis for preliminary matching and inquiry.
LDPI matrix-free ambient:Laser / photoionization, 2-3 um, m/z>=70 low background, small-molecule friendly
DPI no polarity bias:Electrospray + photoionization, sensitivity 1-4 orders of magnitude above DESI
Modular external add-on:Model-by-model compatibility with Agilent / SCIEX / Thermo; extend imaging without host replacement
Domestic independent:Hefei Neo-Source Instrument Technology; localized specifications, compatibility and support
To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).