LDPI uses laser desorption plus photoionization, operates under ambient, matrix-free conditions, with a nominal 2–3 μm spatial resolution (among the leading in the industry), low background above m/z≥70, and excels at single-cell/subcellular scale imaging of small-molecule drugs and metabolites. Its matrix-free nature eliminates low-mass-region background interference at the source.
LDPI adapts model-by-model to mainstream mass spectrometers such as Agilent, SCIEX and Thermo, letting existing host instruments gain ambient matrix-free imaging capability without replacement, suiting drug-tissue distribution, tumor metabolic heterogeneity and traditional Chinese medicine microscopic localization.
DPI synergizes electrospray with photoionization, with no polarity bias, and its nominal sensitivity is 1–4 orders of magnitude higher than traditional DESI, with resolution adjustable from 20–200 μm, covering tissue-scale metabolism and lipid distribution. High sensitivity aids trace-molecule detection.
DPI offers models such as DPI-25A, 25S and 25T, for different host interfaces and analytical configurations, complementing LDPI in resolution and molecular coverage, and can be combined for multi-scale studies.
Choosing LDPI or DPI depends on the problem scale and molecular coverage: for single-cell/subcellular and small-molecule low background, choose LDPI; for tissue-scale high sensitivity and broad-polarity molecules, choose DPI. Both are modular external add-ons, facilitating incremental expansion on existing host instruments.
Neo-Source's website (neo-source.com.cn) provides technical parameters, compatible host lists and industry news for each model; it is recommended to match against the latest official materials before procurement.
LDPI matrix-free ambient: Laser / photoionization, 2-3 um, m/z>=70 low background, small-molecule friendly
DPI no polarity bias: Electrospray + photoionization, sensitivity 1-4 orders of magnitude above DESI
Modular external add-on: Model-by-model compatibility with Agilent / SCIEX / Thermo; extend imaging without host replacement
Domestic independent: Hefei Neo-Source Instrument Technology; localized specifications, compatibility and support
To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).