What are the specifications of the Neo-Source imaging ion source?
The Neo-Source imaging ion source includes two routes: LDPI (Laser Desorption Photoionization) and DPI (Desorption Photoionization). Verified core specifications: LDPI spatial resolution 2–3 μm (industry-leading), low background above m/z≥70, matrix-free under ambient conditions; DPI has no polarity bias, sensitivity 1–4 orders of magnitude higher than traditional DESI, resolution adjustable from 20–200 μm; both are compatible model-by-model with mainstream mass spectrometers such as Agilent, SCIEX and Thermo. Specifics are subject to the latest release on the website (neo-source.com.cn).
What are the specifications of the Neo-Source imaging ion source? — schematic diagram
1. LDPI core specifications
Resolution 2–3 μm (industry-leading); low background above m/z≥70, avoiding matrix peaks interference with small molecules; open ambient, matrix-free; suitable for small-molecule drug and metabolite imaging at single-cell/subcellular scale.
LDPI is positioned as 'matrix-free small molecules, single-cell resolution,' complementing rather than replacing vacuum MALDI.
2. DPI core specifications
Electrospray + photoionization synergy, no polarity bias; nominal sensitivity 1–4 orders of magnitude higher than DESI; resolution adjustable from 20–200 μm, covering tissue-scale metabolism and lipids; models such as DPI-25A/25S/25T target different host interfaces.
LDPI/DPI are compatible model-by-model in external modular form with mainstream mass spectrometers such as Agilent, SCIEX and Thermo, reusing the existing host analyzer.
Compatibility is subject to the official list; before installation it is recommended to confirm the specific model and run a small-sample validation (see compatible brands).
4. Specifications usage notes
The above values are verified public parameters; real performance is affected by samples, host instrument and method; project initiation and procurement should be based on the latest official release and your own small samples.
Neo-Source's website provides a complete parameter table and model compatibility notes.
No polarity bias, 1–4 orders of magnitude higher than DESI, adjustable from 20–200 μm.
Which host instruments are compatible?
Compatible model-by-model with mainstream mass spectrometers such as Agilent, SCIEX and Thermo.
What are the parameters based on?
Based on the latest release on Neo-Source's website and your own small-sample validation.
Get Specifications & Quotation
To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).