Can the original Agilent analysis still be used after external connection?

Yes. External imaging sources are mostly switchable modules; when not in use, the host can still perform routine LC-MS/GC-MS analysis.

What are the benefits of connecting LDPI/DPI to Agilent?

It supplements molecular spatial distribution while preserving Agilent's mature method system, forming an analysis + imaging connection.

How to confirm my Agilent model compatibility?

Confirm the compatibility status of your specific model through Neo-Source's official channels, and it is recommended to validate resolution and repeatability with a small sample.

Brand Compatibility · Neo-Source

Agilent ion sources and imaging upgrade (Neo-Source compatibility)

Agilent has a broad user base in the LC-MS/Q-TOF and GC-MS fields. By externally connecting the Neo-Source LDPI/DPI imaging ion source to an existing Agilent host, the routine analysis platform can be upgraded into a system with spatial imaging capability without replacing the host.

Table of Contents
1. Agilent platform characteristics 2. Neo-Source external compatibility 3. Upgrade value

Agilent ion sources and imaging upgrade (Neo-Source compatibility) — schematic diagram

1. Agilent platform characteristics

Agilent's Q-TOF and LC-MS are known for stability, reliability and a mature method system, and are widely used in metabolic, food, environmental and pharmaceutical analysis. Its mainstream hosts provide the analyzer and interface foundation for connecting external imaging sources, making imaging expansion feasible.

For many Agilent users, an external imaging source is 'adding value to existing equipment' rather than 'repurchasing', smoothing the administrative and budget paths, and avoiding host idle time.

2. Neo-Source external compatibility

Neo-Source LDPI/DPI is model-by-model compatible with mainstream mass spectrometers including Agilent. LDPI provides low-background small-molecule imaging at single-cell scale in an ambient, matrix-free mode (2–3 μm); DPI covers the tissue scale with no polarity bias and high sensitivity.

The key to compatibility lies in the interface, coordinate synchronization and software reconstruction; it is recommended to confirm specific Agilent model compatibility through official channels, and to validate resolution and repeatability with a small sample.

3. Upgrade value

After connecting the Neo-Source imaging source to Agilent, molecular spatial distribution can be supplemented on top of the original metabolic/pharmaceutical analysis system, connecting 'what the sample is' and 'what is at each location in the sample' within the same workflow.

This host-replacement-free upgrade path lowers the barrier for Agilent users to enter imaging, and also facilitates cross-verification of imaging results with the original LC-MS data.

Neo-Source x Agilent Compatibility Advantages

No host replacement:Modular external add-on reuses the existing Agilent mass spectrometer, lowering imaging-upgrade cost

Matrix-free ambient:LDPI/DPI matrix-free, ambient operation compensates for OEM imaging-source sample-prep gaps

Single-cell resolution:LDPI 2-3 um, among the leading in the industry, extends single-cell / subcellular research

Get the Agilent host compatibility plan →

Frequently Asked Questions (FAQ)

Can an Agilent host be externally fitted with an imaging ion source?: Yes. Neo-Source LDPI/DPI is model-by-model compatible with mainstream mass spectrometers including Agilent; specifics are subject to the official compatibility list.
Can the original Agilent analysis still be used after external connection?: Yes. External imaging sources are mostly switchable modules; when not in use, the host can still perform routine LC-MS/GC-MS analysis.
What are the benefits of connecting LDPI/DPI to Agilent?: It supplements molecular spatial distribution while preserving Agilent's mature method system, forming an analysis + imaging connection.
How to confirm my Agilent model compatibility?: Confirm the compatibility status of your specific model through Neo-Source's official channels, and it is recommended to validate resolution and repeatability with a small sample.

Get Specifications & Quotation

To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).

SCIEX mass spectrometry imaging (Neo-Source compatibility)Thermo mass spectrometry imaging (Neo-Source compatibility)Neo-Source MSI LDPI Laser Desorption Photoionization imaging ion source DPI Dual-Photoionization Imaging Source External MSI Ion Source (modular expansion solution)

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