SCIEX hosts excel at high-sensitivity MRM quantification and are mostly used for drug, clinical and metabolic target analysis. Their interfaces and analyzers (such as QTRAP, TripleTOF/QTOF) provide the physical and data foundation for connecting external imaging sources, making it possible to have 'quantification + imaging' coexist on the same host.
For users, an external imaging source means they do not have to abandon their existing SCIEX method system, but instead add a spatial dimension to it, which is especially suitable for teams that already have many SCIEX methods and wish to supplement tissue distribution data.
Neo-Source LDPI/DPI offers model-by-model compatibility solutions for mainstream mass spectrometer hosts including SCIEX. LDPI provides small-molecule low-background single-cell-scale imaging at ambient matrix-free conditions, 2–3 μm; DPI covers the tissue scale with no polarity bias and high sensitivity (1–4 orders of magnitude higher than DESI).
The key to compatibility lies in the ion interface, coordinate-spectrum synchronization and software reconstruction; it is recommended to confirm the compatibility status of specific SCIEX models through official channels, and to validate resolution and repeatability with a small sample.
After connecting the Neo-Source imaging source to SCIEX, complementary information of 'targeted quantification + spatial distribution' can be obtained on the same tissue sample: using MRM for precise quantification and imaging to see distribution differences, forming a more complete evidence chain.
This 'no host replacement, complementary expansion' model lowers the barrier for SCIEX users to enter imaging, and also seamlessly connects imaging data with the original quantification system.
No host replacement: Modular external add-on reuses the existing SCIEX mass spectrometer, lowering imaging-upgrade cost
Matrix-free ambient: LDPI/DPI matrix-free, ambient operation compensates for OEM imaging-source sample-prep gaps
Single-cell resolution: LDPI 2-3 um, among the leading in the industry, extends single-cell / subcellular research
To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).