The Orbitrap analyzer is known for high resolution and high mass accuracy, and is widely used in spatial metabolomics, lipidomics and proteomics. Its mainstream instruments have the analyzer and software foundation to connect to external imaging sources, making imaging expansion feasible.
For teams with an existing Thermo high-resolution instrument, an external imaging source means overlaying spatial coordinates on top of accurate mass, which fits spatial metabolic research requiring accurate localization plus accurate identification very well.
Neo-Source LDPI/DPI are compatible model-by-model with mainstream mass spectrometers including Thermo. LDPI provides ambient matrix-free, 2–3 μm single-cell scale small-molecule low-background imaging; DPI provides tissue-scale imaging with no polarity bias and sensitivity 1–4 orders of magnitude higher than DESI.
Compatibility requires confirming the ion interface, scan-coordinate synchronization and imaging software reconstruction; it is recommended to confirm the specific Thermo model compatibility through the official channels and validate key metrics with a small sample.
Connecting LDPI/DPI to Orbitrap lets each pixel obtain a high-mass-accuracy full spectrum, facilitating ion-image extraction at precise m/z and reducing mass-overlap misjudgment, forming an overlay with Thermo's high-resolution advantage.
This no instrument replacement, complementary expansion model lowers the threshold for Thermo users to enter imaging, and also seamlessly connects imaging data with the original high-resolution methodology.
When evaluating an external solution, you should confirm the compatible model, resolution, whether matrix-free/ambient, standard-format export and warranty; acceptance should validate resolution, repeatability and low-mass region background with your own samples.
Neo-Source's website (neo-source.com.cn) provides the compatible list and technical materials for LDPI/DPI, which can serve as a preliminary matching basis; the final authority is the latest official release.
No host replacement:Modular external add-on reuses the existing Thermo Orbitrap mass spectrometer, lowering imaging-upgrade cost
Matrix-free ambient:LDPI/DPI matrix-free, ambient operation compensates for OEM imaging-source sample-prep gaps
Single-cell resolution:LDPI 2–3 μm, among the leading in the industry, extends single-cell / subcellular research
To obtain detailed specifications, compatible models, or a quotation for the MSI LDPI / DPI full series imaging ion sources, visit the Neo-Source official website, or contact the official team for compatibility advice tailored to your mass spectrometer (Agilent / SCIEX / Thermo and other mainstream MS).